Mariners at White Sox prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Mariners (27-20) are in Chicago to take on the White Sox (15-34).  —  Logan Evans is slated to take the mound for Seattle against Shane Smith for Chicago.

Tigers at Cardinals Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21  —  Its Wednesday, May 21 and the Tigers (32-17) are in St. Louis to take on the Cardinals (27-22).  —  Brant Hurter is slated to take the mound for Detroit against Andre Pallante for St. Louis.

Orioles at Brewers prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Orioles (15-32) are in Milwaukee to take on the Brewers (24-25).  —  Tomoyuki Sugano is slated to take the mound for Baltimore against Chad Patrick for Milwaukee.

Astros at Rays Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21  —  Its Wednesday, May 21 and the Astros (25-23) are in Tampa to take on the Rays (22-26).  —  Hunter Brown is slated to take the mound for Houston against Taj Bradley for Tampa Bay.

Cubs at Marlins prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Cubs (29-20) are in Miami to take on the Marlins (19-28).  —  Cade Horton is slated to take the mound for Chicago against Max Meyer for Miami.

Reds at Pirates prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Reds (25-25) are in Pittsburgh to take on the Pirates (16-33).  —  Brady Singer is slated to take the mound for Cincinnati against Andrew Heaney for Pittsburgh.

How Phillies will navigate a bullpen without José Alvarado — in the short and longer term  —  DENVER — On the second day without their most-trusted reliever, the Phillies' bullpen door opened for a man who had not pitched in eight days.  Joe Ross tossed a scoreless seventh inning on 14 pitches.

Will Phillies trade for reliever after Alvarado suspension?  —  The Trade Deadline is more than two months away, but following José Alvarado's 80-game suspension for violating the league's Joint Drug Prevention and Treatment program, the Phillies find themselves in the market for a late-inning reliever.