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12:10 PM ET, May 21, 2025

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 Top News: 
Vaughn Dalzell / NBCSports.com:
Mets at Red Sox prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  It's Wednesday, May 21 and the Mets (29-20) are in Boston to take on the Red Sox (25-25).  Tylor Megill is slated to take the mound for New York against Garrett Crochet for Boston.
RELATED:
Vaughn Dalzell / NBCSports.com:
Rangers at Yankees Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21  —  It's Wednesday, May 21, and the Rangers (25-24) are in Bronx to take on the Yankees (28-19).  Jacob deGrom is slated to take the mound for Texas against Ryan Yarbrough for New York.
NBCSports.com:
Angels at Athletics prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  It's Wednesday, May 21, and the Angels (22-25) take on the Athletics (22-27).  Jack Kochanowicz is slated to take the mound for Los Angeles against JP Sears for Oakland.
NBCSports.com:
Royals at Giants prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Royals (27-23) are in San Francisco to take on the Giants (29-20).  —  Daniel Lynch is slated to take the mound for Kansas City against Logan Webb for San Francisco.
Discussion: Royals Review
NBCSports.com:
Mariners at White Sox prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Mariners (27-20) are in Chicago to take on the White Sox (15-34).  —  Logan Evans is slated to take the mound for Seattle against Shane Smith for Chicago.
Discussion: South Side Sox
NBCSports.com:
Tigers at Cardinals Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21  —  Its Wednesday, May 21 and the Tigers (32-17) are in St. Louis to take on the Cardinals (27-22).  —  Brant Hurter is slated to take the mound for Detroit against Andre Pallante for St. Louis.
Discussion: MLive.com
NBCSports.com:
Orioles at Brewers prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Orioles (15-32) are in Milwaukee to take on the Brewers (24-25).  —  Tomoyuki Sugano is slated to take the mound for Baltimore against Chad Patrick for Milwaukee.
NBCSports.com:
Reds at Pirates prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Reds (25-25) are in Pittsburgh to take on the Pirates (16-33).  —  Brady Singer is slated to take the mound for Cincinnati against Andrew Heaney for Pittsburgh.
NBCSports.com:
Astros at Rays Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21  —  Its Wednesday, May 21 and the Astros (25-23) are in Tampa to take on the Rays (22-26).  —  Hunter Brown is slated to take the mound for Houston against Taj Bradley for Tampa Bay.
Discussion: DRaysBay
NBCSports.com:
Cubs at Marlins prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Cubs (29-20) are in Miami to take on the Marlins (19-28).  —  Cade Horton is slated to take the mound for Chicago against Max Meyer for Miami.
Vaughn Dalzell / NBCSports.com:
Royals at Giants Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 20
Discussion: Mercury News and Royals Review
NBCSports.com:
Mariners at White Sox prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 20
Discussion: South Side Sox
Vaughn Dalzell / NBCSports.com:
Diamondbacks at Dodgers Prediction: Odds, expert picks, starting pitchers, betting trends, stats for May 20
NBCSports.com:
Braves at Nationals Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 20
NBCSports.com:
Astros at Rays prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 20
Discussion: The Crawfish Boxes
Corey Seidman / NBC Sports Philadelphia:
Phillies encouraged by Painter's progress; Nola sore but improving  —  DENVER — The Phillies are encouraged by how Andrew Painter's arm has responded after six minor-league starts and will extend him a bit farther on Wednesday night.  —  Painter's limit will be five innings and 75 pitches …
Discussion: Phillies Nation
RELATED:
Jen McCaffrey / New York Times:
Juan Soto was impressed with Red Sox free-agency pursuit: ‘They showed a lot of love’  —  BOSTON — The Boston Red Sox pushed hard to sign Juan Soto this offseason.  The 26-year-old superstar said he was impressed with their presentation and strongly considered signing with the team …
Associated Press:
Orioles GM Elias speaks 3 days after firing manager, says he's evaluating reasons for team's decline  —  MILWAUKEE — Orioles general manager Mike Elias broke his silence about his decision to fire manager Brandon Hyde, saying Tuesday he's doing an across-the-board evaluation to determine …
 
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 More News: 
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Brewers' William Contreras showing that his fractured finger won't limit his hitting productivity
Discussion: Winnipeg Free Press
Associated Press:
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New York Daily News:
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TMZ.com:
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