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3:40 PM ET, May 21, 2025

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 Top News: 
NBCSports.com:
Padres at Blue Jays prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Padres (27-19) are in Toronto to take on the Blue Jays (23-24).  Randy Vásquez is slated to take the mound for San Diego against Kevin Gausman for Toronto.
RELATED:
Vaughn Dalzell / NBCSports.com:
Braves at Nationals Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21  —  It's Wednesday, May 21, and the Braves (24-24) are in Washington to take on the Nationals (22-27).  AJ Smith-Shawver is slated to take the mound for Atlanta against Trevor Williams for Washington.
NBCSports.com:
Phillies at Rockies prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Phillies (30-18) are in Denver to take on the Rockies (8-40).  Taijuan Walker is slated to take the mound for Philadelphia against Carson Palmquist for Colorado.
Vaughn Dalzell / NBCSports.com:
Mets at Red Sox prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  It's Wednesday, May 21 and the Mets (29-20) are in Boston to take on the Red Sox (25-25).  Tylor Megill is slated to take the mound for New York against Garrett Crochet for Boston.
Discussion: Yahoo Sports
NBCSports.com:
Royals at Giants prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Royals (27-23) are in San Francisco to take on the Giants (29-20).  —  Daniel Lynch is slated to take the mound for Kansas City against Logan Webb for San Francisco.
Discussion: Royals Review
Vaughn Dalzell / NBCSports.com:
Rangers at Yankees Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21  —  It's Wednesday, May 21, and the Rangers (25-24) are in Bronx to take on the Yankees (28-19).  Jacob deGrom is slated to take the mound for Texas against Ryan Yarbrough for New York.
NBCSports.com:
Reds at Pirates prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Reds (25-25) are in Pittsburgh to take on the Pirates (16-33).  —  Brady Singer is slated to take the mound for Cincinnati against Andrew Heaney for Pittsburgh.
NBCSports.com:
Astros at Rays Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21  —  Its Wednesday, May 21 and the Astros (25-23) are in Tampa to take on the Rays (22-26).  —  Hunter Brown is slated to take the mound for Houston against Taj Bradley for Tampa Bay.
Discussion: DRaysBay
NBCSports.com:
Cubs at Marlins prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21  —  Its Wednesday, May 21 and the Cubs (29-20) are in Miami to take on the Marlins (19-28).  —  Cade Horton is slated to take the mound for Chicago against Max Meyer for Miami.
NBCSports.com:
Tigers at Cardinals Prediction: Odds, expert picks, starting pitchers, betting trends and stats for May 21  —  Its Wednesday, May 21 and the Tigers (32-17) are in St. Louis to take on the Cardinals (27-22).  —  Brant Hurter is slated to take the mound for Detroit against Andre Pallante for St. Louis.
Discussion: MLive.com and Viva El Birdos
NBCSports.com:   Angels at Athletics prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21
NBCSports.com:   Orioles at Brewers prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21
NBCSports.com:
Mariners at White Sox prediction: Odds, expert picks, starting pitchers, betting trends, and stats for May 21
Discussion: South Side Sox
Associated Press:
Mariners' rotation set to get a boost with return of George Kirby for Astros series  —  CHICAGO — Seattle workhorse right-hander George Kirby is expected to start and make his season debut when the Mariners open a four-game series in Houston.  —  Kirby has been on the injured list since March 24 …
Discussion: Winnipeg Free Press
Associated Press:
Orioles activate Andrew Kittredge from 15-day injured list  —  MILWAUKEE — Baltimore Orioles reliever Andrew Kittredge is off the 15-day injured list, clearing the way for the right-hander to make his season debut.  —  The Orioles announced before their game at Milwaukee that they had activated Kittredge …
Corey Seidman / NBC Sports Philadelphia:
Phillies encouraged by Painter's progress; Nola sore but improving  —  DENVER — The Phillies are encouraged by how Andrew Painter's arm has responded after six minor-league starts and will extend him a bit farther on Wednesday night.  —  Painter's limit will be five innings and 75 pitches …
Discussion: Phillies Nation
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 More News: 
Jack Harris / Los Angeles Times:
Reinforcements soon? Injured Dodgers pitchers, including Shohei Ohtani, are finally progressing
Discussion: Yahoo Sports and True Blue LA
Kiley McDaniel / ESPN:
Updated 2025 top 50 MLB prospects: Anthony, Chandler, more
Discussion: True Blue LA
 Earlier Picks: 
Associated Press:
Brewers' William Contreras showing that his fractured finger won't limit his hitting productivity
Discussion: Winnipeg Free Press
 

 
From WeSmirch:

New York Daily News:
Peter Greene, 60, actor in ‘Pulp Fiction,’ ‘The Mask,’ found dead in NYC apartment

Charlotte Griffiths / Daily Mail:
Andrew Mountbatten-Windsor set to swap Royal Lodge for ‘shoebox-sized’ temporary property on remote part of King's estate

TMZ.com:
Lady Gaga Halts ‘Mayhem Ball’ Show After Dancer Falls Off Stage

 
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